The MDLinx editors covered 4 interesting medical conferences during the month of July with a focus on dermatology, AIDS, ENT, cancer, and gastrointestinal cancer. Some of the highlights follow.
As reported at the ESMO 18th World Congress on Gastrointestinal Cancer held in Barcelona, Spain, June 29–July 2 July, anti-IL-1α antibody is effective in patients with metastatic colorectal cancer who have failed standard therapy (oxaliplatin and irinotecan). Patients treated with anti-IL-1α monoclonal antibody (n=207) had a 33% treatment responsecompared with 19% in patients treated with placebo. There was also a 26% relative risk reduction in adverse events.
Use of a free flap with a bone component and the need for a blood transfusion are predictive of post-operative complications in patients undergoing head and neck surgery, as reported by researchers at the 9thInternational Conference on Head and Neck Cancer, which was held in Seattle, WA, July 16-20. Among the 500 consecutive cases, 172 (34.4%) had post-operative complications (most often wound and pulmonary complications).
The 21st International AIDS Conference was held in Durban, South Africa, July 18-22. It was reported that expression of CD8 T cell checkpoint markers are associated with immune activation and disease progression. One hundred twenty-two patients from the SPARTAC trial with primary HIV infections were randomized to receive short-term ART or no therapy. Specifically, it was shown that PD-1 is associated with the plasma viral load and CD4 count, while Lag-3 is associated with the plasma viral load.
As reported at the 2016 American Academy of Dermatology Summer Meeting held in Boston, MA, July 28-31, patients with atopic dermatitis in combination with another atopic disease (asthma or allergic rhinitis) had an increased incidence of pneumonia, influenza, sinusitis, and head/chest colds compared with patients with atopic dermatitis alone. Of note, patients with atopic dermatitis alone are at increased risk for pneumonia, influenza, streptococcal pharyngitis, tonsillitis, sinusitis, and head/chest colds.