Oncology News Articles

Colonoscopy reduces CRC death

Posted on Jul 30, 2012 12:46:00 AM

As published in the Journal of Clinical Oncology, patients with colorectal cancer who underwent colonoscopy prior to diagnosis had a lower mortality rate than patients who did not.  The mortality rate was also lower in patients with distal vs. proximal lesions, and patients who underwent colonoscopy performed by a gastroenterologist.

read this Clinical Oncology article at mdlinx.com

Tags: colorectal, cancer, Oncology

NSAIDs protect against skin cancer

Posted on Jun 10, 2012 4:03:00 PM

As published in Cancer, NSAIDs decrease the risk of squamous cell carcinoma (SCC; IRR=0.85) and malignant melanoma (MM; IRR=0.87).  Aspirin, non-selective NSAIDs, and selective COX-2 inhibitor useanalyzed in all incident cases of SCC (n=1974), basal cell carcinoma (n=13316), and MM (n=3242) recorded in northern Denmark between 1991 and 2009.  Long-term (>7 years) and high intensity use (> 25% prescription coverage during entire interval of use) were particularly protective.

Read more on Cancer

Tags: Oncology

Adenomatous polyps in first-degree relatives increase risk for CRC

Posted on Jun 3, 2012 4:01:00 PM

As published in the Annals of Internal Medicine, a meta-analysis of the extant literature (1966-2011) suggests that first-degree relatives with adenomatous polyps impart an increased risk of colorectal cancer (RR = 2.27-4.36).

more articles on colorectal cancer

Tags: Oncology

Low-dose aspirin decreases risk of metastasis

Posted on May 14, 2012 1:49:00 AM

As published in The Lancet, an analysis of five large randomized studies conducted in the UK has shown that low-dose aspirin (>75 mg/d) for vascular disease prophylaxis decreases the risk of distant metastases.  The analysis included 17,285 patients with 987 incident solid cancers during a mean follow-up of 6.5 y.  The HRs for distant metastases in all cancers, adenocarcinomas, and other solid cancers were 0.64, 0.54, and 0.82, respectively.    Further, the HR for cancer-related death in patients with adenocarcinomas was 0.50.

More on low-dose aspirin

Tags: Preventive Medicine, Oncology

Top Read Oncology Articles in 2011

Posted on Dec 13, 2011 11:35:00 AM

Top Read Oncology Articles in 2011


MDLinx.com

1. Adjuvant gemcitabine versus Neoadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable Pancreatic Cancer: A randomized multicenter phase III study (NEOPAC study)
BMC Cancer     Full Text   

2. Low–dose decitabine versus best supportive care in elderly patients with intermediate– or high–risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: Final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
Journal of Clinical Oncology

3. Randomized trial of carboplatin versus radiotherapy for stage I seminoma
Journal of Clinical Oncology

4. Duration of chemotherapy for metastatic breast cancer: A systematic review and meta–analysis of randomized clinical trials
Journal of Clinical Oncology

 
 

5. Sentinel lymph node biopsy compared with axillary lymph node dissection in early breast cancer: A meta–analysis
Breast Cancer Research and Treatment

6. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double–blind randomised phase 3 study
The Lancet Oncology - Online First

7. Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab–naive or rituximab–sensitive, follicular lymphoma: A randomised phase 3 trial
The Lancet Oncology - Online First

8. Primary radiotherapy versus radical prostatectomy for high–risk prostate cancer
Cancer

9. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial
JAMA

10. Chemotherapy versus tamoxifen versus chemotherapy plus tamoxifen in node–positive, estrogen receptor–positive breast cancer patients. Very late results of the gruppo di ricerca per la chemio–ormonoterapia adiuvante (GROCTA) 01–Trial in early breast cancer
Breast Cancer Research and Treatment

Read all Oncology articles at MDLinx.com

Tags: Oncology news article, oncology Top Articles 2011

MDLinx Focus on Pancreas

Posted on Nov 22, 2011 9:02:00 AM

MDLinx Focus on Pancreas

 

Top New Pancreas Articles

Ranked, sorted, and summarized by MDLinx editors from the latest literature

This month's best articles from 153 contributor journals


F–FDG PET/CT influences management in patients with known or suspected pancreatic cancer Internal Medicine Journal

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination Full Text   Investigational New Drugs


Coexistent ampullary squamous cell carcinoma with adenocarcinoma of the pancreatic duct Full Text    Saudi Journal of Gastroenterology

 

Search all Oncology articles at MDLinx.com/oncology

Tags: Oncology news article, Oncology

Focus on Bone Cancer - Best of MDLinx Oncology

Posted on Oct 25, 2011 10:00:00 AM

MDLinx Focus on Bone

A Best of Oncology Report
MDLinx.com

Top New Bone Articles

Ranked, sorted, and summarized by MDLinx editors from the latest literature

This month's best articles from 153 contributor journals

Prostate–specific membrane antigen: a new potential prognostic marker of osteosarcoma

Medical Oncology

 

Survival from high–grade localised extremity osteosarcoma

Annals of Oncology

 

Bone Metastases: Assessment of Therapeutic Response through Radiological and Nuclear Medicine Imaging Modalities

Clinical Oncology

 

High–throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide–3–kinase and other oncogenes

Cancer

 

Bone Metastasis From Thyroid Cancer Diagnosed by I–131 Whole–Body Scan Without Identifiable Lesion in the Thyroid

Clinical Nuclear Medicine

 

Effect of Ibandronate on Disseminated Tumor Cells in the Bone Marrow of Patients with Primary Breast Cancer: A Pilot Study

Anticancer Research

 

Top Read Articles in Oncology This Month

1. Adjuvant gemcitabine versus Neoadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable Pancreatic Cancer: A randomized multicenter phase III study (NEOPAC study)
BMC Cancer

2. Carboplatin plus paclitaxel versus carboplatin plus pegylated liposomal doxorubicin as first–line treatment for patients with ovarian cancer: The Mito–2 Randomized Phase III Trial
Journal of Clinical Oncology

3. Phase II study of cetuximab as first–line single–drug therapy in patients with unresectable squamous cell carcinoma of the skin
Journal of Clinical Oncology

4. Adjuvant chemotherapy with cisplatin and gemcitabine versus chemotherapy at relapse in patients with muscle–invasive bladder cancer submitted to radical cystectomy: An Italian, multicenter, randomized phase III trial
Annals of Oncology

5. A multicenter analysis of GTX chemotherapy in patients with locally advanced and metastatic pancreatic adenocarcinoma
Cancer Chemotherapy and Pharmacology

6. KRAS mutation in metastatic pancreatic ductal adenocarcinoma: Results of a multicenter phase II study evaluating efficacy of cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first–line therapy
Oncology (Karger)

7. Novel Therapeutic Targets in Non–small Cell Lung Cancer
Journal of Thoracic Oncology

>>See the rest of this Month's Top Read

 

Tags: Oncology news, Oncology news article

Oncology - Focus on Leukemia/lymphoma

Posted on Oct 11, 2011 9:22:00 AM

MDLinx Focus on Leukemia/lymphoma

A Best of Oncology Report

Top New Leukemia/lymphoma Articles

Ranked, sorted, and summarized by MDLinx editors from the latest literature

This month's best articles from 153 contributor journals

Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical–cord blood transplantation for leukemia and myelodysplastic syndrome: A retrospective analysis

The Lancet Oncology - Online First

 

Phase I/II study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia

Blood

 

Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia

European Journal of Haematology

 

Second cancer risk after chemotherapy for Hodgkins lymphoma: A collaborative british cohort study

Journal of Clinical Oncology

 

Prediction of Early Death After Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia With Pretreatment Risk Scores: A Novel Paradigm for Treatment Assignment

Journal of Clinical Oncology

 

Multivariable Model for Time to First Treatment in Patients With Chronic Lymphocytic Leukemia

Journal of Clinical Oncology

 

Favorable outcome in infants with AML after intensive first– and second–line treatment: an AML–BFM study group report

Leukemia

 

TOSO, the Fc{micro} Receptor, Is Highly Expressed on Chronic Lymphocytic Leukemia B Cells, Internalizes upon IgM Binding, Shuttles to the Lysosome, and Is Downregulated in Response to TLR Activation

Journal of Immunology

 

Imatinib Mesylate Therapy Induces Reduction in Neutrophil Gelatinase–Associated Lipocalin Serum Levels and Increase in Leptin Concentrations in Chronic Myeloid Leukemia Patients in Molecular Remission

Acta Haematologica

 

Targeting survivin and p53 in pediatric acute lymphoblastic leukemia

Leukemia

 

Fractionated doses of gemtuzumab ozogamicin with escalated doses of daunorubicin and cytarabine as first acute myeloid leukemia salvage in patients aged 50–70 years old: A phase 1/2 study of the acute leukemia french association (ALFA)

American Journal of Hematology

 

Prognostic value of cytogenetics in adult patients with Philadelphia–negative acute lymphoblastic leukemia

Annals of Hematology

 

Is obesity a prognostic factor for acute myeloid leukemia outcome

Annals of Hematology

 

Synergistic effects of combination with fludarabine and carboplatin depend on fludarabine–mediated inhibition of enhanced nucleotide excision repair in leukemia

International Journal of Hematology

 

FLAGIDA–lite is an effective regimen for patients between 70 and 80 years with acute myeloid leukemia or refractory anemia with excess blasts–2 and is feasible as outpatient treatment

American Journal of Hematology

 

BRIT1/MCPH1 Expression in Chronic Myeloid Leukemia and Its Regulation of the G2/M Checkpoint

Acta Haematologica

 

Quantitative analyses of DAPK1 methylation in AML and MDS

International Journal of Cancer

 

Gastrointestinal manifestations of leukemia

Journal of Gastroenterology and Hepatology

 

Circulating IL–17 levels during the peri–transplant period as a predictor for early leukemia relapse after myeloablative allogeneic stem cell transplantation

Annals of Hematology

 

Dysmegakaryopoiesis, a Clue for an Early Diagnosis of Familial Platelet Disorder With Propensity to Acute Myeloid Leukemia in Case of Unexplained Inherited Thrombocytopenia Associated With Normal–sized Platelets

journal of Pediatric Hematology and Oncology


MDLinx.com

 

Author Commentary Exclusive

Author-posted comments are available on the following article summaries

Anti–EGFR–targeting agents in recurrent or metastatic head and neck carcinoma: A meta–analysis
Head & Neck     Evidence Based Medicine   

 
 

Tags: Oncology news, Oncology news article, best of oncology news

Focus on Pediatric Cancer - Best of MDLinx Oncology

Posted on Sep 20, 2011 10:30:00 AM

MDLinx Focus on Pediatric

A Best of Oncology Report

Top New Pediatric Articles

Ranked, sorted, and summarized by MDLinx editors from the latest literature

This month's best articles from 153 contributor journals

Paternal occupational exposure to pesticides and risk of neuroblastoma among children: A meta–analysis Evidence Based Medicine   

Cancer Causes and Control

 

Intensive short–term chemotherapy regimen induces high remission rate (over 90%) and event–free survival both in children and adult patients with advanced sporadic burkitt lymphoma/leukemia

American Journal of Hematology

 

The Alpha–Globin Genotype Does not Influence Sickle Cell Disease Severity in a Retrospective Cross–Validation Study of the Pediatric Severity Score

European Journal of Haematology

 

Phase II Study of oral capsular 4–hydroxyphenylretinamide (4–HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma

Clinical Cancer Research

 

The company malaria keeps: how co–infection with Epstein–Barr virus leads to endemic Burkitt lymphoma

Current Opinion in Infectious Diseases

 

Nausea, Pain, Fatigue, and Multiple Symptoms in Hospitalized Children With Cancer

Oncology Nursing Forum

 

Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology

Journal of Neuro-Oncology

 

ETV6–RUNX1–positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy

Leukemia

 

Self–report versus medical record – perinatal factors in a study of infant leukaemia: a study from the Children's Oncology Group

Paediatric and Perinatal Epidemiology

 

Find all Oncology news articles at MDlinx.com

Tags: Oncology news article, Oncology, best of oncology news

Different Characteristics of Thymomas With and Without Myasthenia Gravis

Posted on Sep 14, 2011 10:44:00 AM

Different Characteristics of Thymomas With and Without Myasthenia Gravis

Annals of Surgical Oncology, 09/14/2011

MDLinx.com

Yu L et al. – Myasthenia gravis (MG) seldom occurs in types A and C thymoma. MG of some thymoma patients was not caused by thymoma, but by the paraneoplastic thymus. The prognosis of thymomas with MG is similar to that without MG. The main cause of death is myasthenia crisis for thymoma patients with MG and stage IV and/or type C for thymoma patients without MG...read more

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Tags: Oncology news, Myasthenia Gravis, Oncology