Comparative Long Term Effects of Nebivolol and Carvedilol in Hypertensive Heart Failure Patients
Posted on Wed, Aug 31, 2011
Comparative Long Term Effects of Nebivolol and Carvedilol in Hypertensive Heart Failure Patients
Journal of Cardiac Failure, 08/31/2011 Clinical Article
Marazzi G et al. – In the long term, nebivolol and carvedilol appear to be similarly effective in the treatment of hypertensive patients with chronic heart failure (CHF).
Methods
- A total of 160 hypertensive CHF patients, with LVEF <40% and in New York Heart Association (NYHA) functional class I, II, or III, were randomly assigned to receive nebivolol or carvedilol for 24 months.
- At baseline and at the end of treatment, all patients underwent clinical evaluation, echocardiography, and 6–minute walking test.
- The target doses were 10 mg/d for nebivolol and 50 mg/d for carvedilol.
Results
- Compared with baseline values, LVEF increased by a similar extent in the carvedilol (C) and nebivolol (N) groups (C from 36.1% (SD 1.5%) to 40.9% (SD 1.9%), P < .001; N from 34.1% (SD 1.8%) to 38.5% (SF 2.2%), P < .001).
- Heart rate and NYHA functional class decreased significantly in ...read more
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