Takahashi Y et al. – This study showed adverse effects of decreased serum potassium and increased serum uric acid with trichlormethiazide treatment, and suggested that a lower dose of trichlormethiazide may minimize these adverse effects. These findings support the current trend in hypertension therapeutics to shift towards lower doses of thiazides.

• Authors used data from the Clinical Data Warehouse of Nihon University School of Medicine obtained between Nov 1, 2004 and July 31, 2010, to identify cohorts of new trichlormethiazide users (n=99 for 1 mg, n=61 for 2 mg daily dosage) and an equal number of non–users (control).
• Authors used propensity–score matching to adjust for differences between users and control for each dosage, and compared serum chemical data including serum sodium, potassium, uric acid, creatinine and urea nitrogen.
• The mean exposure of trichlormethiazide of 1 mg and 2 mg users was 58 days and 64 days, respectively.

• The mean age was 66 years, and 55% of trichlormethiazide users of the 1 mg dose were female. ...read more

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